| ProductName | BCellLymphoma10 |
| Size | 6,000U |
| Description | Bcl-10isanintracellularsignalingproteinidentifiedfromthet(1;14)(p22;q32)breakpointinMALTlymphomas.ThehumanBcl10geneencodesaproteinof233aminoacidscontaininganN-terminalcaspaserecruitmentdomain(CARD)thatmediatesself-oligomerizationandtheC-terminalregionofBcl-10(1-3).Bcl10isexpressedubiquitouslywithhighexpressionlevelsinlymphoidtissuesandinthedevelopingcentralnervesystem(4-6).MutationshavebeenfoundincasesoffollicularlymphomaanddiffuselargeBcelllymphoma(7).Bcl-10isapositiveregulatorofantigen-receptorinducedNF-kBactivation.Bcl-10-initiatedactivationofNF-kBcanbeinhibitedbycotransfectionofdominant-negativemutantsofTRAF2,NIK,IKKaorIkBa(3-5,8). |
| Applications |
|
| Source | Baculovirus-insectcell |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unit=1ngpurifiedprotein. |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 8915 |
| Accession# | NM_003921 |
| GeneName | B-cellCLL/lymphoma10 |
| GeneSymbol | BCL10 |
| GeneSynonyms | CLAP;mE10;CIPER;c-E10;CARMEN |
| MW | 27.9kDa |
| ProteinSequence | MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTS SRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCS SCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVG RTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ |
| StorageBuffer | 20mMTris-HClpH7.9,100mMNaCl,0.2mMEDTA,1mMDTTand20%glycerol |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Willis,T.G.etal.,(1999)Cell96,35-45 2.Zhang,Q.etal.,(1999)Nat.Genet.22,63-68 3.Srinivasula,S.M.etal.,(1999)J.Biol.Chem.274,17946-17954 4.Costanzo,A.etal.,(1999)J.Biol.Chem.274,20127-20132 5.Koseki,T.etal.,(1999)J.Biol.Chem.274,9955-9961 6.Thome,M.etal.,(1999)J.Biol.Chem.9962-9968 7.Du,M.Q.etal.,(2000)Blood95,3885-3890 8.Ruland,J.etal.,(2001)Cell104,33-42 |
德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。
No.
货号 | 规格 | |||
Excellgen | GeneExpresso™Max Transfection Reagent | 2 | EG-1089 | 1ml |
Excellgen | Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre) | 4 | EG-1069 | 1 mg |
Excellgen | Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 1 mg | |||
Excellgen | serine/threonine kinase 33, STK33 | 7 | EG-261 | 100 µg |
Excellgen | Alpha-tubulin Rabbit Polyclonal Antibody | 9 | EG-1000 | 100 µg |
Excellgen | Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b) | 11 | EG-156 | 100 µg |
Excellgen | Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts | 13 | EG-266 | 100 µg |
Excellgen | Flag Tag Mouse Monoclonal Antibody (2C5) | 15 | EG-277 | 100 µg <span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;"> |
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