Excellgen/MDM2 (Mouse double minute 2) Human Oncoprotein/RP-118/10,000 U,Excellgen,,Excellgen,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Excellgen/MDM2 (Mouse double minute 2) Human Oncoprotein/RP-118/10,000 U

产品编号：RP-118

市场价：¥5200.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>其它动物抗原>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$260.00

品牌： Excellgen

公司：Excellgen, Inc.

公司分类：

商品介绍

ProductName	MDM2(Mousedoubleminute2)HumanOncoprotein
Size	10,000U
Description	OriginallydiscoveredasoneofthreegenesamplifiedondoubleminutechromosomesinatumOrigenicderivativeofNIH3T3cells(1),MDM2waslatershowntopossessoncogenicpotentialwhenoverexpressed(2,3).High-levelexpressionofMDM2hasalsobeenshowntoconfertumorigenicpotentialuponnontransformedrodentfibroblastsinathymicnudemice(2,3).MDM2canimmortalizeratembryofibroblastsandcancooperatewithactivatedRAStotransformthesecells(3).ElevatedlevelsofMDM2proteinhavebeenfoundinavarietyofhumantumors,mostnotablyinsofttissuesarcomaswhereupto30%ofprimarytumorscontainmultiplecopiesoftheMDM2gene(4).OnemechanismbywhichMDM2overexpressionpromotestumordevelopmentisthroughitsABIlitytobindtothep53tumorsuppressor,therebyblockingthetransactivation(5-7),cellcyclearrest(8),andapoptoticfunctionsofp53(9).MDM2caninhibitp53activityinanumberofwaysincludingpreventingp53fromrecruitingTAFs,promotingnuclearexport,inhibitingp53acetylation,andperhapsmostimportantlybyvirtueofitsfunctionasanE3ubiquitinligasewithspecificityfor,amongothers,p53(reviewedin10).Inadditiontoregulatingp53levelsbytargetingp53forproteasomaldegradationMDM2alsotransfersubiquitintoitself,MDMX,theß2adrenergicreceptor,glucocorticoidreceptor,TIP60,andPCAF(10).
Applications	invitrotranscriptionassays,DNA-proteinandprotein-proteininteractionassays
Source	E.coli
FusionTag	6XHis
PurificationMethod	FPLC
UnitDefinition(Activity)	1unitequalsto1nanogramofpurifiedprotein
Purity	~95%asdeterminedbySDS-PAGE
GeneID	4193
Accession#	NM_002392
GeneName	MDM2oncogene,E3ubiquitinproteinligase
GeneSymbol	MDM2
GeneSynonyms	HDMX;hdm2;ACTFS
MW	57.8kDa
ProteinSequence	1mvrsrqmcntnmsvptdgavttsqipaseqetlvrpKPLllkllksvgaqkdtytmkevl 61fylgqyimtkrlydekqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvnqqe 121ssdsgtsvsenrchleggsdqkdlvqelqeekpssshlvsrpstssrrraiseteensde 181lsgerqrkrhksdsislsfdeslalcvireiccerssssestgtpsnpdldagvsehsgd 241wldqdsvsdqfsvefevesldsedyslseegqelsdeddevyqvtvyqagesdtdsfeed 301peisladywkctscnemnpplpshcnrcwalrenwlpedkgkdkgeisekaklenstqae 361egfdvpdckktivndsrescveenddkitqasqsqesedysqpstsssiiyssqedvkef 421ereetqdkeesvesslplnaiepcvicqgrpkngcivhgktghlmacftcakklkkrnkp 481cpvcrqpiqmivltyfp
StorageBuffer	20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA
Storage	-20to-80°C.
Shipping	4°Cordryice
References	1.Cahilly-Snyder,L.,etal.,(1987)Somat.CellMol.Genet.13:235-244. 2.Fakharzadeh,S.etal.,(1991)EMBOJ.10:1565-1569 3.Finlay,C.A.,(1993)Mol.Cell.Biol.13:301-306 4.Leach,F.S.,etal.,(1993)CancerRes.53:2231-2234. 5.Momand,J.,etal.,(1992)Cell69:1237-1245. 6.Oliner,J.D.,etal.,(1992)Nature358:80-83 7.Oliner,J.D.,etal.,(1993)Nature362:857-860 8.Chen,J.,etal.,(1996)Mol.Cell.Biol.16:2445-2452. 9.Dornan,D.,etal.,(2004)Nature429:86-92 10.BondGL,etal.,(2005)CurrentCancerDrugTargets.5(1):3-8.

品牌介绍

德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。

No.

货号	规格
Excellgen	GeneExpresso™Max Transfection Reagent	2	EG-1089	1ml
Excellgen	Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre)	4	EG-1069	1 mg
Excellgen	Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 1 mg
Excellgen	serine/threonine kinase 33, STK33	7	EG-261	100 µg
Excellgen	Alpha-tubulin Rabbit Polyclonal Antibody	9	EG-1000	100 µg
Excellgen	Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b)	11	EG-156	100 µg
Excellgen	Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts	13	EG-266	100 µg
Excellgen	Flag Tag Mouse Monoclonal Antibody (2C5)	15	EG-277	100 µg <span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;">