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主营类目:Ferrous Scraps,Petroleum By-Products,蛋白肽,逆转录酶等
℡ 4000-520-616
℡ 4000-520-616
Excellgen/HIF-1a NTAD (Hypoxia-Inducible Factor 1 alpha N-Terminal Activation Domain (530-698)/RP-120/10,000 U
产品编号:RP-120
市  场 价:¥5000.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$250.00
品      牌: Excellgen
公      司:Excellgen, Inc.
公司分类:
Excellgen/HIF-1a NTAD (Hypoxia-Inducible Factor 1 alpha N-Terminal Activation Domain (530-698)/RP-120/10,000 U
商品介绍
ProductNameHIF-1aNTAD(Hypoxia-InducIBLeFactor1alphaN-TerminalActivationDomain(530-698)
Size10,000U
DescriptionHypoxia-induciblefactor-1(HIF1)isatranscriptionfactorfoundinmammaliancellsculturedunderreducedoxygentensionthatplaysanessentialroleincellularandsystemichomeostaticresponsestohypoxia.HIF1isaheterodimercomposedofanalphasubunitandabetasubunit.Thebetasubunithasbeenidentifiedasthearylhydrocarbonreceptornucleartranslocator(ARNT).ThisgeneencodesthealphasubunitofHIF-1.HIF-1alphacontainstwotransactivationdomainslocatedbetweenaminoacids531and826.Overexpressionofanaturalantisensetranscript(aHIF)ofthisgenehasbeenshowntobeassociatedwithnonpapillaryrenalcarcinomas.Twoalternativetranscriptsencodingdifferentisoformshavebeenidentified.SpecificdisruptionoftheHIF-1pathwayisimportantforexploringitsroleintumorBIOLOGyanddevelopingmoreefficientweaponstotreatcancer(1).HIF-1alphaisamasterregulatorofthehypoxicresponse,anditsproangiogenicactivitiesinclude,butarenotlimitedto,regulationofvascularendothelialgrowthfactor(VEGF)(2).HIF-1alphaproteinexpressionoftenseenininvasivebreastcancer(3).RecentdatademonstratesthatHIF-1alphaknockdownreducestumOrigenicityofMCF-7cellsandsuggestapromisingcombinationofbothanti-HIF-1strategyandtrADItionalchemotherapytoimprovecancertreatment(4)
Applications
  • protein-proteininteractionassays
  • invitrotranscriptionassays
  • cellgrowthassays
SourceE.coli
FusionTag6XHis
PurificationMethodFPLC
UnitDefinition(Activity)1unitequalsto1nanogramofpurifiedprotein
Purity

~95%asdeterminedbySDS-PAGE

GeneID3091
Accession#NM_001530
GeneNamehypoxiainduciblefactor1,alphasubunit(basichelix-loop-helixtranscriptionfactor)
GeneSymbolHIF1A
GeneSynonymsHIF1;MOP1;PASD8;HIF-1A;bHLHe78;HIF-1alpha;HIF1-ALPHA
MW19.8kDa
ProteinSequenceEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTT
StorageBuffer20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA
Storage-20to-80°C.
Shipping4°Cordryice
References1.Semenza,G.L.etal.,(1994)J.Biol.Chem.269(38),23757-23763
2.Corley,K.M.etal.,(2005)J.Cell.Biochem.96(5),971-985
3.Vleugel,M.M.,etal.,(2005)CancerGenet.Cytogenet.163(2),168-172
4.Li,J.,etal.(2006)Biochem.Biophys.Res.Commun.342(4),1341-1351
品牌介绍

德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。

No.

货号

规格




Excellgen

GeneExpresso™Max Transfection Reagent

2

EG-1089

1ml

Excellgen

Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre)

4

EG-1069

1 mg

Excellgen

Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 

1 mg




Excellgen

serine/threonine kinase 33, STK33

7

EG-261

100 µg

Excellgen

Alpha-tubulin Rabbit Polyclonal Antibody

9

EG-1000

100 µg

Excellgen

Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b)

11

EG-156

100 µg

Excellgen

Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts

13

EG-266

100 µg

Excellgen

Flag Tag Mouse Monoclonal Antibody (2C5)

15

EG-277 

100 µg

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