| ProductName | MAD(MAXdimerizationprotein1,MXD1) |
| Size | 10,000U |
| Description | MAXdimerizationproteinbelongstoasubfamilyofMAX-interactingproteins.ThisproteincompeteswithMYCforbindingtoMAXtoformasequence-specificDNA-bindingcomplex,actingasatranscriptionalrepressor(whileMYCappearstofunctionasanactivator)andisacandidatetumorsuppressor.BothMycandMad,aswellasthemorerecentlydescribedMntandMgaproteins,formheterodimerswithMax,permittingbindingtospecificDNAsequences.TheseDNA-boundheterodimersrecruitcoactivatororcorepressorcomplexesthatgeneratealterationsinchromatinstructure,whichinturnmodulatetranscription(1).Thewild-typec-Mycandc-Myc/MadBRproteinshaveindistinguishableBIOLOGicalactivityandtargetgenerecognitioninvivo(2) |
| Applications | DNAbinding,proliferation,differentiation,andapoptosisresearchstudies |
| Source | E.coli |
| FusionTag | Flag |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 4084 |
| Accession# | NM_002357 |
| GeneName | MAXdimerizationprotein1 |
| GeneSymbol | MXD1 |
| GeneSynonyms | MAD;MAD1;BHLHC58 |
| MW | 26.6kDa |
| ProteinSequence | MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRST HNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQID QLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSS SSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL |
| StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Grandori,C.,etal.Annu.Rev.CellDev.Biol.16,653-699(2000) 2.Nikiforov,M.A.,etal.J.Biol.Chem.278(13),11094-11099(2003) |
德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。
No.
货号 | 规格 | |||
Excellgen | GeneExpresso™Max Transfection Reagent | 2 | EG-1089 | 1ml |
Excellgen | Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre) | 4 | EG-1069 | 1 mg |
Excellgen | Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 1 mg | |||
Excellgen | serine/threonine kinase 33, STK33 | 7 | EG-261 | 100 µg |
Excellgen | Alpha-tubulin Rabbit Polyclonal Antibody | 9 | EG-1000 | 100 µg |
Excellgen | Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b) | 11 | EG-156 | 100 µg |
Excellgen | Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts | 13 | EG-266 | 100 µg |
Excellgen | Flag Tag Mouse Monoclonal Antibody (2C5) | 15 | EG-277 | 100 µg <span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;"> |
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