Excellgen/Retinoid X Receptor-alpha Ligand Binding Domain/RP-143/10,000 U,Excellgen,,Excellgen,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Excellgen/Retinoid X Receptor-alpha Ligand Binding Domain/RP-143/10,000 U

产品编号：RP-143

市场价：¥4200.00

场地：美国(厂家直采)

产品分类：分子类>克隆和表达>转录表达>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$210.00

品牌： Excellgen

公司：Excellgen, Inc.

公司分类：

商品介绍

ProductName	RetinoidXReceptor-alphaLigandBindingDomain
Size	10,000U
Description	RetinoidXreceptor(RXR)servesasapromiscuousheterodimerizationpartnerformanynuclearreceptorsthroughtheidentitybox,a40-aminoacidsubregionwithintheligandbindingdomain(LBD).RXRpartnersincludethyroidhormonereceptors(TRs),retinoicacidreceptors(RARs),peroxisomeproliferator-activatedreceptor,severalconstitutiveactiveorphannuclearreceptors(e.g.nucleargrowthfactorI-B),oxysterolreceptors,andconstitutiveandrostanereceptors.RXRsalsoformhomodimerstomediatetheeffectsof9-cis-retinoicacid(9-cRA).Dependingontheseprotein-proteininteractions,RXR-containingcomplexeshavedistinctligand-dependentandconstitutivefunctions(1,2).TheLBDisfunctionallycomplexandmediatesligandbinding,receptorhomo-andheterodimerization,repressionoftranscriptionintheabsenceofligand,andligand-dependentactivationoftranscription(3).HormonebindingtothestructurallyconservedLBDoftheRXRtriggersaconformationalchangethatprincipallyaffectstheconservedC-terminaltransactivationhelixH12involvedintranscriptionalactivation(4).Coactivatorsdirectlyrecruitedbyligandedreceptorsincludemembersofthesteroidreceptorcoactivator/p160familysuchasSRC-1,transcriptionalintermediaryfactor2/glucocorticoidreceptorinteractingprotein1,andRAC3/activatorofthyroidandretinoicacidreceptors/amplifiedinbreastcancer1(5).
Applications	invitrotranscriptionassays DNAandprotein-proteininteractionsassays
Source	E.coli
FusionTag	6XHis
PurificationMethod	FPLC
UnitDefinition(Activity)	1unitequalsto1nanogrampurifiedprotein.20unitsaresufficientforaninvitrotranscriptionassayand100unitsaresufficientforaligandbindingoraprotein-proteininteractionassay
Purity	~95%asdeterminedbySDS-PAGE
GeneID	6256
Accession#	NM_002957
GeneName	retinoidXreceptor,alpha
GeneSymbol	RXRA
GeneSynonyms	NR2B1
MW	32.0kDa
ProteinSequence	MGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLN PSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRS IAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFN PDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLF FFKLIGDTPIDTFLMEMLEAPHQMT
StorageBuffer	20mMTris-HCl,pH8.0,250mMNaCl,50%Glycerol
Storage	-20to-80°C.
Shipping	4°Cordryice
References	1.Mangelsdorfetal.,(1995)Cell83,841-850 2.Mangelsdorfetal.,(1995)Cell83,835-839 3.Nakashimaetal.,(1999)Science284,479-482 4.Egeaetal.,(2001)J.Mol.Biol.307,557-576 5.Leoetal.,(2000)Gene245,1-11

品牌介绍

德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。

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