| ProductName | Liver-XReceptoralphaisoform |
| Size | 10,000U |
| Description | LiverXreceptors(LXRs)arenuclearreceptorsthatregulatethemetabolismofcholesterolandbileacids(1).TherearetwosubtypesofLXRs,LXRαandLXRβ.LXRβispreferentiallyexpressedinliver,smallintestine,kidneyandspleen(2,3).Incontrast,LXRαexpressionisubiquitous(4).ThegenomicstructureandthepromoterregionsofthetwoLXRgenescontainspecificregulatorysites,whichsuggestthatLXRsmayhavephysiologicalrolesintheimmunesystem(5).Likeothernuclearreceptors,LXRsheterodimerizewithretinoidXreceptor(RXR)forfunction(1).LXRsareactivatedbynaturallyoccurringoxysterolsandregulatetheexpressionoftargetgenes(6-8),includingATPbindingcassettetransporter1(ABC1),ATPbindingcassettetransporter8(ABC8)andcholesterolestertransferprotein(CETP)(9-10).LXRαisthoughttoplayamajorroleinthecontrolofcholesterolcatabolismbystimulatingtheexpressionofcholesterol7alpha-hydroxylase(CYP7A1),theratelimitingenzymeofbileacidsynthesis(11) |
| Applications | LXRhasbeenappliedinDNAandprotein-proteininteractionsassays |
| Source | E.coli |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.20unitsaresufficientforagel-mobilityshiftassayand100unitsaresufficientforaprotein-proteininteractionassay |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 10062 |
| Accession# | NM_005693 |
| GeneName | NR1H3 |
| GeneSynonyms | NR1H3;LXRAandRLD-1 |
| MW | 53.7kDa |
| ProteinSequence | SLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAA EPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGF FRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKR QEEEQAHATSLPPRRSSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMA PDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLE TSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIA ISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVH SEQVFALRLQDKKLPPLLSEIWDVHE |
| StorageBuffer | 20mMTris-HCl,pH8.0,250mMNaCl,50%Glycerol |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Peetetal.,(1998)Curr.Opin.Gent.Dev.8,571-575 2.Willyetal.,(1995)GenesDev.9,1033-1045 3.Apfeletal.,(1994)Mol.Cell.Biol.14,7025-7035 4.Songetal.,(1994)Proc.Natl.Acad.Sci.91,10809-10813 5.Albertietal.,(2000)Gene243,93-103 6.Janowskietal.,(1996)Nature383,728-731 7.Lehmannetal.,(1997)J.Biol.Chem.272,3137-3140 8.Janowskietal.,(1999)Proc.Natl.Acad.Sci.96,266-271 9.Luoetal.,(2000)J.Clin.Invest.105,513-520 10.Venkateswaranetal.,(2000)J.Biol.Chem.275,14700-14707 11.Peetetal.,(1998)Cell93,693-704 |
德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。
No.
货号 | 规格 | |||
Excellgen | GeneExpresso™Max Transfection Reagent | 2 | EG-1089 | 1ml |
Excellgen | Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre) | 4 | EG-1069 | 1 mg |
Excellgen | Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 1 mg | |||
Excellgen | serine/threonine kinase 33, STK33 | 7 | EG-261 | 100 µg |
Excellgen | Alpha-tubulin Rabbit Polyclonal Antibody | 9 | EG-1000 | 100 µg |
Excellgen | Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b) | 11 | EG-156 | 100 µg |
Excellgen | Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts | 13 | EG-266 | 100 µg |
Excellgen | Flag Tag Mouse Monoclonal Antibody (2C5) | 15 | EG-277 | 100 µg <span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;"> |
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