Excellgen/c-myc (proto oncogene)/RP-109/5,000 U,Excellgen,,Excellgen,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Excellgen/c-myc (proto oncogene)/RP-109/5,000 U

产品编号：RP-109

市场价：¥5600.00

场地：美国(厂家直采)

产品分类：蛋白类>重组蛋白>其它动物抗原>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$280.00

品牌： Excellgen

公司：Excellgen, Inc.

公司分类：

商品介绍

ProductName	c-myc(protooncogene)
Size	5,000U
Description	Theuniversalderegulationofc-Mycgeneexpressionintumorcellssuggeststhatthisoncogenerepresentsanattractivetargetforcancertherapeuticpurposes.Thec-Mycpromoterintegratesdiversemitogenicsignallingcascades,whichareconstitutivelyactivatedintumorcells,andtranslatesthemintoexpressionofthec-Myctranscriptionfactor,whichpromotescellproliferation,growth,differentiation,andapoptosisbyregulatingtheexpressionofnumeroustargetgenes(1-3).ThestructuralandbiochemicalfeaturesoftheMYCfamily(MYC,N-MYC,andL-MYC)markthemasdirectregulatorsofgeneexpression.Asbasichelix-loop-helixleucinezipperproteins(bHLH-ZIP),theMYCsacquirethecapacitytobindtheDNAsequenceCACGTG(E-box)whendimerizedwithMAX(anotherbHLH-ZIP,4,5).Ahead-to-tailpairofMYC-MAXdimersmay,inturn,formaheterotetramercapableofbridgingdistantE-boxes(6).AmongthebroadlydistributedpositiveenforcersofMYCactionthatareoftenrecruitedtotargetgenesarechromatinremodeling(SWI/SNFrelatives)andmodifyingcomplexes(TRAPP/GCN5andrelatives);thesecomplexesmobilizenucleosomesandacetylatehistonesand/orothertargetstoactivategeneexpression(4,7,8).MYCbindsTBPalonganauxiliarypathwaytocontrolgeneexpression.MADandMNTgenerallyopposeMYCactionbyenlistinghistonedeacetylasecomplexes.Besidesactingatthelevelofchromatin,MYCmayalsooperateatlaterstagesofthetranscriptioncycle,afterpre-initiationcomplexformation(9).Inadditiontousinggenericchromatincomplexestoup-ordown-regulatetranscription,theMYCnetworkalsoconscriptsindividualfactorstomodifyexpressionlocallyonanadhocbasis.Forexample,YY1,AP2,MIZ1,SP1,BRCA1,andotherproteinsinteractdirectlywithMYC,andsomaydirectlymodifytheoutputoftheMYCnetwork(10,11)
Applications	DNAandprotein-proteininteractionassays
Source	Baculovirus-insectcell
FusionTag	6XHis
PurificationMethod	FPLC
UnitDefinition(Activity)	1unit=1ngofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;50unitsaresufficientforreconstitutedtranscriptionassayand100unitsaresufficientforaprotein-proteininteractionassay.
Purity	~95%asdeterminedbySDS-PAGE
GeneID	4609
Accession#	NM_002467
GeneName	v-mycavianmyelocytomatosisviraloncogenehomolog
GeneSymbol	MYC
GeneSynonyms	MRTL;MYCC;c-Myc;bHLHe39
MW	50.4kDa
ProteinSequence	1mplnvsftnrnydldydsvqpyfycdeeenfyqqqqqselqppapsediwkkfellptpp 61lspsrrsglcspsyvavtpfslrgdndggggsfstadqlemvtellggdmvnqsficdpd 121detfikniiiqdcmwsgfsaaaklvseklasyqaarkdsgspnparghsvCSTsslylqd 181lsaaasecidpsvvfpyplndssspkscasqdssafspssdsllsstesspqgspeplvl 241heetppttssdseeeqedeeeidvvsvekrqapgkrsesgspsagghskpphsplvlkrc 301hvsthqhnyaappstrkdypaakrvkldsvrvlrqisnnrkctsprssdteenvkrrthn 361vlerqrrnelkrsffalrdqipelennekapkvvilkkatayilsvqaeeqkliseedll 421rkrreqlkhkleqlrnsca
StorageBuffer	20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA
Storage	-20to-80°C.
Shipping	4°Cordryice
References	1.Dangetal.,(1999)Exp.CellRes.253,63-77 2.Grandorietal.,(2000)Annu.Rev.CellDev.Biol.16,653-699 3.Eisenman(2001)Genes&Dev.15,2023-2030 4.McMahonetal.,(2000)Mol.Cell.Biol.20,556-562 5.Bouchardetal.,(2001)Genes&Dev.15,2042-2047 6.NairandBurley(2003)Cell112,193-205 7.Chengetal.,(1999)Nat.Genet.22,102-105 8.Luscher(2001)Gene277,1-14 9.EberhardyandFarnham(2001)J.Biol.Chem.276,48562-48571 10.Shrivastavaetal.,(1996)Proc.Natl.Acad.Sci.93,10638-10641 11.SakamuroandPrendergast(1999)Oncogene18,2942-2954.

品牌介绍

德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。

No.

货号	规格
Excellgen	GeneExpresso™Max Transfection Reagent	2	EG-1089	1ml
Excellgen	Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre)	4	EG-1069	1 mg
Excellgen	Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 1 mg
Excellgen	serine/threonine kinase 33, STK33	7	EG-261	100 µg
Excellgen	Alpha-tubulin Rabbit Polyclonal Antibody	9	EG-1000	100 µg
Excellgen	Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b)	11	EG-156	100 µg
Excellgen	Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts	13	EG-266	100 µg
Excellgen	Flag Tag Mouse Monoclonal Antibody (2C5)	15	EG-277	100 µg <span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;">