| ProductName | FGF-1(acidicfibroblastgrowthfactor) |
| Size | 5,000U |
| Description | Acidicfibroblastgrowthfactor(FGF-1)andbasicfibroblastgrowthfactor(FGF-2)areubiquitouscytokinesfoundinmanytissues.Theyhaveeffectsonmultiplecelltypesderivedfrommesodermandneuroectoderm,includingendothelialcells(1).FGFproteinsaresmallpeptidesof155to268aminoacidresidues(2-4).Thedegreeofsequenceidentitybetweendifferentfamilymembersis30-60%ina"centraldomain"of~120aminoacids.ThisdomainconferstoFGFsacommontertiarystructureandtheABIlitytobindtoheparin(5).SecretedFGFssignaltotargetcellsbybindingandactivatingcell-surfacetyrosinekinaseFGFreceptors(FGFRs;6,7).ThefunctionofFGFsandFGFRsduringembryonicdevelopmentandadultphysiologyhasbeenaddressedbygain-andloss-of-functionexperimentsinseveralanimalmodelorganisms.ThesestudieshaveshownthatFGFsactaskeyregulatorsofdevelopmentalevents(8,9). |
| Source | Baculovirus-insectcell |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.20unitsaresufficientforaDNA-proteinassayand100unitsaresufficientforaprotein-proteininteractionassay |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 2246 |
| Accession# | NM_000800 |
| GeneName | fibroblastgrowthfactor1(acidic) |
| GeneSymbol | FGF1 |
| GeneSynonyms | AFGF;ECGF;FGFA;ECGFA;ECGFB;FGF-1;HBGF1;HBGF-1;GLIO703;ECGF-beta;FGF-alpha |
| MW | 19.2kDa |
| ProteinSequence | MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQ LSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEK NWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD |
| StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.SlavinJ.,(1995)CellBiolInt.5,431-44. 2.Cuevas,P.,etal.,(1995)NeurolRes17,396-399 3.DeMoerlooze,L.,etal.,(2000)Development127,483-492 4.Hebert,JM,etal.,(1990)DevBiol138,454-463 5.Faham,S.,etal.,(1996)Science271,1116-1120 6.Dionne,CA,etal.,(1990)EMBOJ9,2685-2692 7.Johnson,DE,andWilliamsLT(1993)AdvCancerRes60,1-41 8.Arman,E,etal.,(1998)ProcNatlAcadSciUSA95,5082-5087 9.Gage,FH.(2000)Science287,1433-1438 |
德国Excellgen特色产品包括Cre重组蛋白、ExcellScript 耐热 M-MuLV (MMLV) 逆转录酶、FLP重组蛋白、GeneExpresso™ Max转染试剂。
No.
货号 | 规格 | |||
Excellgen | GeneExpresso™Max Transfection Reagent | 2 | EG-1089 | 1ml |
Excellgen | Cre Recombinase, TAT-Cre (Tat-NLS-Cre, HTNC, HTNCre) | 4 | EG-1069 | 1 mg |
Excellgen | Human Protein Kinase Alpha, PKA, C alpha, cAMP-dependent protein 1 mg | |||
Excellgen | serine/threonine kinase 33, STK33 | 7 | EG-261 | 100 µg |
Excellgen | Alpha-tubulin Rabbit Polyclonal Antibody | 9 | EG-1000 | 100 µg |
Excellgen | Recombinant Human Interferon alpha-2b, IFN alpha 2b, (rHuIFN-α2b) | 11 | EG-156 | 100 µg |
Excellgen | Thermus aquaticus Muts DNA mismatch repair protein, 6X His-Taq-Muts | 13 | EG-266 | 100 µg |
Excellgen | Flag Tag Mouse Monoclonal Antibody (2C5) | 15 | EG-277 | 100 µg <span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;"> |
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